“生物制造与生物芯片”课题组

研究方向：

1、生物制造：生物制造是一门以细胞、活性分子和生物材料为基本单元的仿生结构体的制造科学，是工程、材料、信息和生命科学交叉的新兴学科。生物制造的科学、技术和应用广泛应用于仿生制造、功能结构生物体制造、再生医学模型制造、体外生物/病理/药理模型制造及以细胞和活性分子为基础的细胞/组织/器官芯片和先进医疗诊断设备的制造。

2、生物芯片：生物微流体芯片技术是将生物医学过程集成到一块微米尺度的芯片上， 以模拟体内生物过程、药物响应等过程。由于它在生物、医学等领域的巨大潜力，已经发展成为一个生物、化学、医学、流体、电子、材料、机械等学科交叉的崭新研究领域。

[1] Yaqi Wang, Feng Tian, Yujie Duan, Zhuogang Li, Qiaotong Chen, Jiaying Chen, Xiaomin Miao, Yanhong Xu, Chulan Xu, Yadong Tang*. In vitro 3D cocultured tumor-vascular barrier model based on alginate hydrogel and Transwell system for anti-cancer drug evaluation [J]. Tissue and Cell, 2022, 76: 101796. 

[2] Junjie Xiong, Han Wang, Xingzi Lan, Yaqi Wang, Zixu Wang, Jianfu Bai, Weicheng Ou, Nian Cai, Wenlong Wang and Yadong Tang*. Fabrication of bioinspired grid-crimp micropatterns by melt electrospinning writing for bone–ligament interface study [J]. Biofabrication, 2022, 14: 025008.

[3]  Chunliang Zhang, Diwei Mo, Juncheng Guo, Wenlong Wang*, Shangbin Long, Houyao Zhu, Danying Chen, Guanghua Ge and Yadong Tang*. A method of crack detection based on digital image correlation for simulated cracked tooth [J]. BMC Oral Health, 2021, 21:539. 

[4]  Zixu Wang, Han Wang, Junjie Xiong, Jiahao Li, Xiaomin Miao, Xingzi Lan, Xujie Liu, Wenlong Wang, Nian Cai, Yadong Tang*. Fabrication and in vitro evaluation of PCL/gelatin hierarchical scaffolds based on melt electrospinning writing and solution electrospinning for bone regeneration [J]. Materials Science and Engineering: C, 2021: 128: 112287.

[5]   Xingzi Lan, Yurong Liu, Yaqi Wang, Feng Tian, Xiaomin Miao, Han Wang, Yadong Tang*. Coaxial electrospun PVA/PCL nanofibers with dual release of tea polyphenols and ε-poly (L-lysine) as antioxidant and antibacterial wound dressing materials [J]. International Journal of Pharmaceutics, 2021, 601: 120525.

[6]     Xingzi Lan, Han Wang, Jianfu Bai, Xiaomin Miao, Quan Lin, Jianpei Zheng, Shukai Ding, Xiaoran Li, Yadong Tang*. Multidrug-loaded electrospun micro/nanofibrous membranes: fabrication strategies, release behaviors and applications in regenerative medicine [J]. Journal of Controlled Release, 2021, 330: 1264-1287.

[7]   Xiaomin Miao, Yaqi Wang, Jiaying Chen, Xingzi Lan, Xiaohan Zeng, Yadong Tang* and Kun Zhang*. Research Progress in Cardiac Tissue Model for in vitro Drug Evaluation [J]. Progress in Biochemistry and Biophysics, 2021, 48(3): 275-286.

[8]      Ying Zhou, Xiaomin Miao, Xingzi Lan, Junren Luo, Tingting Luo, Zhixin Zhong, Xifeng Gao , Zihui Mafang, Junjie Ji, Han Wang and Yadong Tang*. Angelica Essential Oil Loaded Electrospun Gelatin Nanofibers for Active Food Packaging Application [J]. Polymers, 2020, 12, 299.

[9]      Jianfu Bai, Han Wang, Wei Gao, Feng Liang, Zixu Wang, Ying Zhou, Xingzi Lan, Xun Chen, Nian Cai, Weimin Huang and Yadong Tang*. Melt electrohydrodynamic 3D printed Poly (e-caprolactone)/Polyethylene glycol/Roxithromycin scaffold as a potential anti-infective implant in bone repair [J]. International Journal of Pharmaceutics, 2020, 576: 118941.

[10]      Yadong Tang*, Xingzi Lan, Chengfeng Liang, et al. Honey loaded alginate/PVA nanofibrous membrane as potential bioactive wound dressing [J]. Carbohydrate Polymers, 2019, 219: 113–120. 

[11]      Yadong Tang*, Ying Zhou, Xingzi Lan, Dongchao Huang, Tingting Luo,  Junjie Ji, Zihui Mafang, Xiaomin Miao, Han Wang, and Wenlong Wang*. Electrospun Gelatin Nanofibers Encapsulated with Peppermint and Chamomile Essential Oils as Potential Edible Packaging [J]. Journal of Agricultural and Food Chemistry, 2019, 67: 2227−2234. (封面论文，ESI高被引论文)

[12]      Feng Liang, Han Wang, YaJu Lin, Ying Zhou, Zhifeng Wang, Xindu Chen, Nian Cai, Fanwen Yang, Peixuan Wu, Yunbo He, Yadong Tang*. Near-field melt electrospinning of poly(ε-caprolactone) (PCL) microline array for cell alignment study [J]. Materials Research Express, 2019, 6, 015401.

[13]      Jun Zeng, Han Wang, Yaru Lin, Jiarong Zhang, Xin Chen, Xindu Chen, Zhifeng Wang, Nian Cai, Yadong Tang*, Peixuan Wu*. Fabrication of microfluidic channels based on melt-electrospinning direct writing. Microfluidics and Nanofluidics, 2018, 22: 23.

[14]      Yadong Tang, Boxin Huang, Yuqin Dong, Wenlong Wang, Xi Zheng, Wei Zhou, Kun Zhang & Zhiyun Du*. Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy[J], Journal of Biomaterials Science, Polymer Edition, 2017, 28（14）:1603-1616.

[15]      Yadong Tang, Francesco Paolo Ulloa Severino, Federico Iseppon, Vincent Torre*, Yong Chen*. Patch method for culture of primary hippocampal neurons [J]. Microelectronic Engineering, 2017, 175: 61-66.

[16]  Yadong Tang, Li Liu, Junjun Li, Leqian Yu, Li Wang, Jian Shi and Yong Chen*. Induction and differentiation of human induced pluripotent stem cells into functional cardiomyocytes on a compartmented monolayer of gelatin nanofibers [J]. Nanoscale, 2016, 8(30): 14530-14540.

[17]  Yadong Tang, Li Liu, Junjun Li, Leqian Yu, Francesco Paolo Ulloa Severino, Li Wang, Jian Shi, Xiaolong Tu, Vincent Torre and Yong Chen*. Effective motor neuron differentiation of human induced pluripotent stem cells on a patch made of crosslinked monolayer gelatin nanofibers [J]. Journal of Materials Chemistry B, 2016, 4, 3305-3312.

[18]  Yadong Tang, Jianmiao Liu, Yong Chen*. Agarose multi-wells for tumor spheroid formation and anti-cancer drug test [J]. Microelectronic Engineering, 2016, 158: 41-45.

[19]  Yadong Tang, Jian Shi, Sisi Li, Li Wang, Yvon E. Cayre & Yong Chen*. Microfluidic device with integrated microfilter of conical-shaped holes for high efficiency and high purity capture of circulating tumor cells [J]. Scientific reports, 2014, 4.

[20]  Yadong Tang, Na Li*, Anjun Liu, et al. Effect of spinning conditions on the structure and performance of hydrophobic PVDF hollow fiber membranes for membrane distillation [J]. Desalination, 2012, 287: 326-339.